The safety of preoperative use of dexmedetomidine in preschool children
10.3760/cma.j.issn.1673-4904.2013.33.008
- VernacularTitle:术前应用右美托咪定对学龄前儿童的安全性探讨
- Author:
Guizhen LIU
;
Fei LIU
;
Yuchuan SUN
- Publication Type:Journal Article
- Keywords:
Anxiety;
Hemodynamics;
Child,preschool;
Stress reaction;
Dexmedetomidine
- From:
Chinese Journal of Postgraduates of Medicine
2013;36(33):23-25
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the degree of cooperation and the effect of hemodynamics in preschool children who received preoperative use of dexmedetomidine.Methods One hundred preschool children who scheduled for lower abdominal operation were randomly divided into two groups,each 50patients.The treatment group was given bolus infusion dexmedetomidine 0.5 μ g/kg (20 ml),the control group was given bolus infusion 0.9％ sodium chloride 20 ml.They were completed in 20 min.The cooperation was assessed by induction compliance checklist (ICC) score,and the level of mean arterial pressure (MAP),heart rate(HR),pulse oxygen saturation(SpO2),end-tidal pressure of carbon dioxide(PnCO2) at monitoring ward before bolus infusion (T1),end of bolus infusion (T2),before induction (T3),after induction (T4),incised skin (T5) and end of operation (T6) were compared.Results The scores ofICC in treatment group was significantly lower than that in control group [(2.73 ± 0.12) scores vs.(6.17 ± 0.91) scores] (P ＜ 0.05).In treatment group,48 patients ICC score was 0,2 patients ICC score ＞5 scores,and in control group,there was 48,2 patients,there was significant difference(P ＜ 0.05).The level of MAP,HR at T1,T2,T4between two groups had no significant difference (P ＞ 0.05).The level of MAP,HR at T3,T5,T6 in treatment group were significantly lower than those in control group(P ＜ 0.05).In control group,the level of MAP,HR at T3,T5,T6 were significantly higher than those at T1 (P ＜ 0.05).In treatment group,the level of MAP,HR at T2-T6 had no significant difference compared with T1 (P ＞ 0.05).The level of SpO2,PnCO2 between two groups and interclass had no significant difference (P ＞0.05).Conclusion Bolus infusion dexmedetomidine before operation can improve the induction of anesthesia and operation smoothly,and improve the patients early rehabilitation.
