Lipoprotein (a) and homocysteine potentiate the risk of coronary artery disease in male subjects

VernacularTitle:脂蛋白(a)、同型半胱氨酸与男性冠状动脉疾病发生的风险研究
Author: Meifeng YAN ; Yunfeng XIAO ; Hongwei CUI
Publication Type:Journal Article
Keywords: Coronary artery disease; Lipoprotein (A); Homocysteine; Male
From: Chinese Journal of Postgraduates of Medicine 2013;36(31):1-4
CountryChina
Language:Chinese
Abstract: Objective To discuss the rehtionship between lipoprotein [Lp (a)],homocysteine (Hcy) and coronary artery disease (CAD) in men.Methods Two hundred and twenty-two male patients admitted for coronary angiography were classified into CAD positive group (111 cases) and CAD negative group (111 cases).The clinical data and plasma Hcy and Lp(a) levels were recorded in both groups.Logistic regression analysis was used to analyze males CAD risk factors.Results Lp (a) ≥0.3 g/L was a risk factor for CAD (OR =5.04,95％ CI 1.88-13.51,P =0.001),whereas Hcy was not related to CAD (OR =1.35,95％ CI 0.63-2.89,P =0.443).However,when both factors were considered together in an interaction model,plasma high Hcy and high Lp (a) levels were risk factors for CAD (OR =11.54,95％ CI 2.62-45.61,P=0.003).Conclusion Plasma Lp (a) and Hcy levels may increase the incidence of male CAD process.