Correlation between liver-type fatty acid binding protein and nonalcoholic fatty liver disease extent and other clinical parameters
10.3760/cma.j.issn.1673-4904.2013.30.007
- VernacularTitle:肝型脂肪酸结合蛋白与非酒精性脂肪性肝病严重程度及其他指标关系探讨
- Author:
Bing LI
;
Qian SHEN
;
Huihong HUANG
;
Juansun GUO
;
Daowei WANG
- Publication Type:Journal Article
- Keywords:
Fatty acid-binding proteins;
Nonalcoholic fatty liver disease
- From:
Chinese Journal of Postgraduates of Medicine
2013;36(30):16-18
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between liver-type fatty acid binding protein (L-FABP) and nonalcoholic fatty liver disease (NAFLD) extent and other clinical parameters.Methods Ninety-six patients of NAFLD (NAFLD group) and 100 cases of healthy controls (control group) were selected.The levels of serum L-FABP and blood biochemical parameters were measured by enzyme-linked immunosorbent assay.The lesion degree was assessed by ultrasound.The body mass index (BMI),waist to hip ratio (WHR) and homeostasis model assessment insulin resistance index (HOMA-IR) were calculated.Results The WHR,BMI,fasting plasma glucose (FBG),triglycerides (TG),alanine aminotransferase (ALT),HOMA-IR and L-FABP in NAFLD group were higher than those in control group,there were statistical differences (P ＜ 0.05).The result of correlation analysis showed L-FABP level was positively related with ALT,TG,FBG,WHR,BMI,HOMA-IR (r =0.735,0.728,0.681,0.713,0.699,0.673 ;P ＜0.05),and negative correlation with HDL-C (r =-0.607,P ＜ 0.05).The L-FABP level in control group was (15.42 ± 2.51) g/L,mild NAFLD was (15.96 ± 2.92) g/L,moderate NAFLD was (17.48 ± 3.91) g/L,serious NAFLD was (25.14 ± 5.37) g/L.There was statistical difference in L-FABP level between serious NAFLD and control group,mild NAFLD,moderate NAFLD (P ＜ 0.05).Conclusion Serum L-FABP level of serious NAFLD patient significantly increases,and L-FABP level is related with biochemical parameters of liver function.
