Clinical effects of neonatal hypoxic-ischemic encephalopathy treated with ganglioside and effects of tumor necrosis factor-α and interleukin-6
10.3760/cma.j.issn.1673-4904.2013.30.002
- VernacularTitle:神经节苷脂治疗新生儿缺氧缺血性脑病的临床效果及其对肿瘤坏死因子α和白细胞介素6的影响
- Author:
Xiurui DENG
;
Zhenlang LIN
;
Qing CHEN
;
Erli QU
- Publication Type:Journal Article
- Keywords:
Hypoxic-ischemic,brain;
Gangliosides;
Tumor necrosis factor-alpha;
Interleukin-6
- From:
Chinese Journal of Postgraduates of Medicine
2013;36(30):4-7
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the application value of ganglioside treated for neonatal hypoxic-ischemic encephalopathy (HIE).Methods The 88 neonatal HIE children were divided into observation group and control group according to random digits table method with 44 cases each.The children in the two groups were given general comprehensive treated measures.The children in observation group were treated with ganglioside.The children in control group were treated with citicoline.The clinical treatment situation,clinical symptoms situation,neonatal behavioral neurological assessment (NBNA) score situation,the changes of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels in the two groups were compared and analyzed.Results The total efficiency in observation group was 90.91％(40/44),in control group was 68.18％ (30/44),there was statistically significant (P ＜ 0.01).The times of reflex recovery,muscle tension recovery and consciousness recovery in observation group were (7.04 ± 1.28),(8.13 ± 1.42) and (5.08 ± 0.90) d,in control group were (10.16 ± 1.57),(10.98 ± 1.33) and (9.76 ± 1.18) d,the targets in observation group were significantly shorter than those in control group (P ＜ 0.05).The change of NBNA score before and after treatment was (10.91 ± 1.83) scores in observation group,which was higher than that in control group [(9.07 ± 1.69) scores],and there was significant difference between the two groups (P＜ 0.05).The change ofTNF-α and IL-6 levels before and after treatment in observation group were (65.78 ± 12.25)and (88.58 ± 18.01) ng/L,which were lower than those in control group [(30.10 ± 11.93) and (32.69 ±17.94) ng/L],and there were significant differences between the two groups (P ＜0.05).Conclusions Ganglioside can be used as an ideal therapeutic drug for neonatal HIE to clinical application.Its mechanism may be related to the reduction of TNF-α and IL-6 levels.
