The relationship between serum cystatin C and coronary artery disease in type 2 diabetes mellitus patients with normal uric protein
10.3760/cma.j.issn.1673-4904.2013.30.001
- VernacularTitle:尿蛋白正常的2型糖尿病患者血清胱抑素C与冠状动脉病变的关系
- Author:
Manman WANG
;
Jiong SHU
;
Xuanrong CHEN
;
Panwei MU
;
Yanming CHEN
;
Longyi ZENG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Coronary disease;
Cystatin C;
320-dynamic volume computed tomography
- From:
Chinese Journal of Postgraduates of Medicine
2013;36(30):1-4
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum cystatin C and coronary artery disease in type 2 diabetes mellitus (T2DM) patients with normal uric protein.Methods According to the coronary artery lesion diagnosed by 320-dynamic volume CT,the 126 T2DM patients with normal uric protein were divided into three groups:no coronary stenosis group (group A,32 cases),coronary atherosclerosis group(group B,38 cases),coronary heart disease group (group C,56 cases).Then the serum cystatin C etc were compared among the three groups.Results The levels of serum cystatin C in group A,B,C were (0.89 ± 0.27),(1.31 ± 0.53),(1.54 ± 0.62) mg/L.With the increase of coronary artery lesions,it gradually increased,there was significant difference among the three groups (P ＜ 0.05).The patients were divided into three groups according to the level of serum cystatin C quartile.The incidence of coronary artery lesion in creased with the increased levels of serum cystatin C.The level of serum cystatin C increased from 75th percentile to 100th percentile,the incidence of coronary heart disease increased significantly (OR =8.32,P ＜0.05).The result of multiple Logistic regression analysis showed that history of hypertension (regression coefficient 4.135,P =0.000),glycosylated hemoglobin (regression coefficient 1.257,P =0.002),low density lipoprotein-cholesterol (regression coefficient 3.381,P =0.015),cystatin C (regression coefficient 2.046,P =0.030) were the independent risks of coronary heart disease in patients with T2DM.Conclusion The level of serum cystatin C may be a predictor for coronary heart disease in T2DM patients with normal uric protein.
