Priming technique can alleviate the withdrawal responses associated with intravenous administration of rocuronium.
10.4097/kjae.2009.56.6.628
- Author:
Jae In LEE
1
;
Se Hun LIM
;
Sang Eun LEE
;
Young Hwan KIM
;
Jeong Han LEE
;
Kun Moo LEE
;
Soon Ho CHEONG
;
Young Kyun CHOE
;
Young Jae KIM
;
Chee Mahn SHIN
Author Information
1. Department of Anesthesiology and Pain Medicine, Busan Paik Hospital, Busan, Korea. anespc@medimail.co.kr
- Publication Type:Original Article
- Keywords:
Lidocaine;
Priming dose;
Rocuronium;
Withdrawal responses
- MeSH:
Administration, Intravenous;
Aged;
Androstanols;
Anesthesia, General;
Humans;
Incidence;
Injections, Intravenous;
Intubation;
Lidocaine;
Unconsciousness
- From:Korean Journal of Anesthesiology
2009;56(6):628-633
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Intravenous injection of rocuronium is associated with withdrawal responses which are attributable to the pain from the injection of rocuronium. Several methods have been proposed to abolish and attenuate rocuronium-induced pain. We hypothesized priming dose of rocuronium could reduce withdrawal responses associated with administering a second large dose of rocuronium for tracheal intubation. We compared the efficacy of the priming dose technique of rocuronium with intravenous lidocaine as a pre-treatment for the prevention of withdrawal responses associated with rocuronium injection. METHODS: We recruited 150 patients aged between 18 and 60 years, ASA physical status 1 or 2, who were going to undergo elective surgery requiring general anesthesia. Patients were allocated into three groups. Group C received normal saline, Group L received lidocaine 1 mg/kg, and Group P received rocuronium 0.06 mg/kg 2 minutes before administering a second large dose of rocuronium for tracheal intubation. After the loss of consciousness, rocuronium 0.6 mg/kg was administered intravenously over 10 seconds for tracheal intubation. The withdrawal responses to the injection of rocuronium were evaluated. RESULTS: The incidence of withdrawal responses associated with rocuronium injection for tracheal intubation was 56, 50, 24% in group C, group L, and group P, respectively. The incidence of withdrawal responses was lower in group P than group C and group L, but there was no difference between group L and group C. CONCLUSIONS: Priming dose technique is a useful clinical method to alleviate withdrawal responses associated with rocuronium injection.
