The application of N-terminal pro-B-type natriuretic peptide, C-reactive protein and D-dimer in evaluating prognosis of elderly patients confined to bed
10.3760/cma.j.issn.1673-4904.2013.28.006
- VernacularTitle:氨基端B型钠尿肽前体、C反应蛋白和D-二聚体在评估老年卧床患者预后中的应用
- Author:
Xiaohong WU
;
Lisong LIU
- Publication Type:Journal Article
- Keywords:
C-reactive protein;
Prognosis;
N-terminal pro-B-type natriuretic peptide;
D-dimer
- From:
Chinese Journal of Postgraduates of Medicine
2013;36(28):16-19
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the value of plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP),C-reactive protein(CRP) and D-dimer(D-D) in prognosis of elderly patients confined to bed.Methods The clinical data of 150 elderly patients confined to bed were reviewed retrospectively,and 35 patients were in dead group and 115 patients were in survival group.The level o f plasma NT-proBNP,CRP and D-D were measured before treatment,during treatment and after treatment.Their characteristics and dynamic change were analyzed,and the value of NT-proBNP,CRP and D-D was evaluated in prognosis of elderly patients confined to bed.Results The level of NT-proBNP,D-D and CRP in dead group before treatment,during treatment and after treatment were significantly higher than those in survival group (P ＜ 0.05 or ＜ 0.01).The peak level of NT-proBNP,D-D and CRP in dead group emerged after treatment.By the way,the peak level of NT-proBNP,D-D and CRP in survival group emerged before treatment.Incidence of two or three markers positive in dead group [37.1％ (13/35),54.3％ (19/35)] was significantly greater than that in survival group [20.9％ (24/115),8.7％ (10/115)] (P =0.032,0.008).Multivariate Logistic regression analysis showed that the level of NT-proBNP,D-D and CRP were independent predictors of 28-day mortality (P ＜0.05).Conclusions The level of NT-proBNP,CRP and D-D are increased in severe elderly hospitalized patients.The level of above indexes have a dynamic change and reach peak before death.They are the independent prognostic markers of hospital mortality.Combined detection of NT-proBNP,D-D and CRP can improve the predictive value of hospital mortality in elderly patients confined to bed.
