The expressive level and clinical significance of tumor necrosis factor ligands related molecule 1A in peripheral blood of patients with viral myocarditis

VernacularTitle:病毒性心肌炎患者外周血肿瘤坏死因子配体相关分子1A表达水平及临床意义
Author: Yuqiang JI ; Mei XIE ; Peiyong LIU ; Zhao ZHAO
Publication Type:Journal Article
Keywords: Myocarditis; Tumor necrosis factor ligands related molecule 1A; Immane injury
From: Chinese Journal of Postgraduates of Medicine 2013;36(28):8-9
CountryChina
Language:Chinese
Abstract: Objective To explore the expressive level and clinical significance of tumor necrosis factor ligands related molecule 1A (TL1A) in peripheral blood of patients with viral myocarditis.Methods In 70 patients with viral myocarditis (viral myocarditis group) and 70 normal controls (control group),the plasma level of TL1A was detected by enzyme linked immunosorbent assay and the mRNA level of TL1A was detected by real-time quantitative reverse transcription polymerase chain reaction.Results The plasma level of TL1A in viral myocarditis group was significantly higher than that in control group [(1.37 ± 0.41) μg/L vs.(0.85 ± 0.22) μg/L](P=0.000).The level of peripheral blood TL1A mRNA in viral myocarditis group was significantly higher than that in control group (0.39 ±0.17 vs.0.31 ±0.11,P =0.001).Conclusion The level of TL1A in patients with viral myocarditis is increased,and TL1A may participate in the occurrence of viral myocarditis.