Analysis of factors relating to serum lutein level in elderly patients with early age-related macular degeneration

VernacularTitle:早期老年黄斑变性患者血清叶黄素水平相关因素分析
Author: Mingfang WANG ; Le MA ; Yangmu HUANG ; Xin XIAO ; Xiaoming LIN
Publication Type:Journal Article
Keywords: Macular degeneration; Lutein; Diet survey
From: Chinese Journal of Geriatrics 2013;32(10):1083-1086
CountryChina
Language:Chinese
Abstract: Objective To explore the factors relating to serum lutein level in elderly patients with early age-related macular degeneration (AMD).Methods 102 early AMD patients diagnosed by international diagnostic criteria were selected.The level of serum lutein was measured by HPLC,and dietary intake was estimated by food-frequency questionnaire (FFQ).The factors relating to serum lutein level were analyzed by Pearson correlation and multiple regression analysis models.Results Serum lutein level was higher in female AMD patients than in male AMD patients [(0.33±0.31) μmol/L vs.(0.21 ±0.19) μmol/L,t=2.21,P＜0.05].Serum lutein level was positively correlated with dietary lutein (r=0.49,P＜ 0.001),but not correlated with age,BMI,and other nutrient intake after adjustment for caloric intake.Dietary lutein was mainly from corn,spinach,leeks,eggs,chrysanthemum,pumpkin,broccoli,lettuce,asparagus and peas.Intakes of spinach,pumpkin,asparagus were significantly associated with serum lutein level.Conclusions Elderly patients with AMD should increase the intakes of lutein-rich vegetables to increase the serum lutein level.