Serum cystatin C level and its risk factors in Chinese healthy adults: a population based cross-section study
10.3760/cma.j.issn.1674-0815.2013.05.009
- VernacularTitle:健康成年人胱抑素C水平分布及相关因素分析
- Author:
Jing LI
;
Li JIAO
- Publication Type:Journal Article
- Keywords:
Adult;
Regression analysis;
Cystatin C
- From:
Chinese Journal of Health Management
2013;7(5):321-324
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the average serum level and risk factors of serum cystatin C in Chinese healthy adults.Methods A total of 15 918 healthy adults who received health assessments in Peking Union Medical College Hospital during January 2012 and March 2013 were enrolled in this crosssection study.Serum cystatin C was measured.Estimated glomerular filtration rate was calculated by creatinine (eGFRcr).Multivariable linear regression analysis was used to assess factors that contribute to cystatin C variability.Results The mean serum cystatin C level was (0.79 ±0.14) mg/L (95％ reference interval (RI) was 0.56-1.08 mg/L).Male showed significantly higher cystatin C level than female (mean (0.84 ±0.13) vs (0.73 ±0.13) mg/L; RI 0.64-1.11 mg/L and 0.54-1.03 mg/L,respectively; P=0.000).Differences between genders are still significant after subgrouped by age.In the young-age group (age≤44 years old),the mean serum cystatin C level was (0.81 ±0.11)mg/L in male and (0.68 ±0.09)mg/L in female,P =0.000.In the middle-age group (45-59 years old),the mean cystatin C level was (0.85 ±0.12) mg/L in male and (0.75 ±0.12) mg/L in female,P =0.000.In the elderly group (≥60 yrs),the mean serum cystatin C level was (0.97 ±0.18) mg/L in male and (0.89 ±0.19) mg/L in female,P =0.000.Serum cystain C was increased with ages (in male:r =0.274,P =0.000 ; in femal,r =0.470,P =0.000).Differences between each two age groups are all significant for both gender,P =0.000.Cystatin C level in male is respectively (0.81 ±0.ll)mg/L,(0.85 ±0.12) mg/L and (0.97 ± 0.18) mg/L in the young-age,middle-age and elderly group.Cystatin C level in female is respectively (0.68 ±0.09) mg/L,(0.75 ±0.12) mg/L and (0.89 ±0.19) mg/L in the young-age,middle-age and elderly group.Male gender,older age,lower body weight,lower eGFRcr,lower high-density lipoprotein cholesterol,lower fasting blood glucose,increased mean blood pressure,higher body mass index and triglyceride were significantly associated with increased serum cystatin C level.Body weight,total cholesterol and low-density lipoprotein cholesterol were not risk factors of cystatin C.Conclusion Serum cystatin C level may be influenced by gender,age and other factors in Chinese healthy adults.
