Plasma soluble triggering receptor expressed on myeloid cells-1 as a marker of sepsis: a meta-analysis
10.3760/cma.j.issn.1671-0282.2013.09.021
- VernacularTitle:血浆可溶性髓样细胞触发受体-1诊断脓毒症价值的Meta分析
- Author:
Du CHEN
;
Shiqi LU
;
Feng XU
;
Wei LI
- Publication Type:Journal Article
- Keywords:
Soluble triggering receptor expressed on myeloid cells-1 (sTREM-1);
Sepsis;
Diagnosis;
Plasma;
C-reaction protein;
Procalcitonin;
Meta-analysis;
Cut-off value
- From:
Chinese Journal of Emergency Medicine
2013;22(9):1025-1029
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of plasma soluble triggering receptor expressed on myeloid cells-1 as a diagnosis marker of sepsis.Methods Articles on plasma soluble triggering receptor expressed on myeloid cells-1 as a marker of sepsis which were public published in the PubMed,Ovid,Springer,Wanfang database from 1991-2012 were searched and conducted a meta-analysis by MetaDiSc and Stata.Results Seven articles were selected to the meta-analysis according to the inclusion criteria,of which cut-off values varied signicantly from studies.Due to the data heterogeneity (I2 ＞ 50％,P ＜0.05),random model was used to pool the effect sizes.The overall combined effect sizes:sensitivity =81％ (95％CI:0.76-0.86); specificity =81％ (95％ CI:0.76-0.86); DOR =30.03 (95％ CI:7.89-114.37) ; AUC of SROC =0.905 9; Q*-0.837 6.Deek' s funnel plot showed little publication bias.Conclusions Plasma soluble triggering receptor expressed on myeloid cells-1 may be a useful adjunctive tool for the diagnosis of sepsis.However,further studies are needed in order to identify the best cut-off value in the diagnosis of sepsis.
