Clinical study on Buyang-huanwu decoction preventing the formation of lower limb deep vein thrombosis after major orthopedic surgery
10.3760/cma.j.issn.1673-4246.2013.11.007
- VernacularTitle:补阳还五汤加味防治骨科术后下肢深静脉血栓形成的临床研究
- Author:
Zhihao LIU
;
Xuefeng XIAO
;
Qiong JIA
- Publication Type:Journal Article
- Keywords:
Preventive medicine;
Buyang-huanwu decoction;
Deep vein thrombosis;
Low molecular heparin;
Major orthopedic surgery
- From:
International Journal of Traditional Chinese Medicine
2013;35(11):982-984
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss Buyang-huanwu decoction preventing the formation of lower limb deep vein thrombosis (DVT) after major orthopedic surgery.Methods 60 patients were randomly divided into a treatment group and a control group.The treatment group was treated with oral liquid of Buyang-huanwu,twice a day; while the control group was treated with 5000IU of low molecular heparin through subcutaneous injection,once daily.Prothrombin time (PT),activated partial thromboplatin time (APTT),fibrinogen (FIB),D-dimer,lower limb deep vein color B ultrasonic and the wound flow changes after 48 hours were observed at 1st,7th,and 14th day after medication.Results ①)Comparison on the incidence of DVT:The incidence of DVT in the treatment group was higher than the control group at 7th day after medication,this incidence turn to equal in the two groups at the 14th day after medication,while at the end of therapy,the incidence of DVT in the treatment group was lower than the control group with significant difference (P＜0.05).②Comparison on D-dimer changes:D-dimer at the 1st and 14th day were (0.782 ± 0.472) mg/1 and (0.320 ± 0.102) mg/1 in the treatment group and (0.720±0.421)mg/1 and (0.417 ± 0.217) mg/l in the control group.Comparing with the same group before treatment [the treatment group was(0.548±0.245)mg/1; the control group was (0.560±0.195) mg/l],D-dimer was increased at the 1 st day with obvious difference (P＜ 0.05),but reduced at the 14th day,without statistical difference (P＞0.05).Conclusion Buyang-huanwu decoction did not show good effects as low molecular heparin at the beginning of the treatment,but the its whole therapeutic effects and safety was better in treating lower limb deep vein thrombosis after major orthopedic surgery.
