Correlation between polymorphism in the promoter of DNA methyltransferase-3B gene and susceptibility of colorectal cancer
10.3760/cma.j.issn.1673-4181.2013.05.003
- VernacularTitle:DNMT3B基因启动子单核苷酸多态性与结直肠癌易感性的关联研究
- Author:
Feng XU
;
Ying YU
;
Jiang ZOU
- Publication Type:Journal Article
- Keywords:
Colon neoplasms;
Rectal neoplasms;
DNA methyltransferase 3B;
Single nucleotide polymorphism
- From:
International Journal of Biomedical Engineering
2013;36(5):266-269
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe and analyze the correlation between the DNA methyltransferase-3B (DNMT3B) gene single nucleotide polymorphisms (SNP) rs 1569686 and the susceptibility to colorectal cancer (CRC) in Tianjin Han population.Methods A case-control study was performed.89 CRC patients and 94 normal controls were examined,and Sequenom MassArray system was applied to detect the genotype of rs1569686 in DNMT3B gene polymorphisms.The association results were analyzed of the SNP and CRC.Results The frequencies of genotypes TT,GT and GG at SNP rs1569686 were 74.2％,24.7％ and 1.1％ in CRC patients respectively,which there were no significant differences from that in controls(73.4％,23.4％ and 3.2％; P＞0.05).Conclusion It suggests that the SNP rs1569686 of DNMT3B gene may not be related to susceptibility of CRC in Tianjin Han population.
