Role of microRNA in asthma
10.3760/cma.j.issn.1673-4408.2013.05.002
- VernacularTitle:微小RNA与哮喘的相关研究进展
- Author:
Jun GU
- Publication Type:Journal Article
- Keywords:
MicroRNA;
Epigenetics;
Asthma;
Biomarker
- From:
International Journal of Pediatrics
2013;40(5):440-442
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs (miRNAs) are small non-coding RNA molecules that negatively regulate gene expression.The miRNAs regulate gene expression by controlling the translation of a specific type of messenger RNA.miRNAs are key epigenetic regulators of gene expression,and miRNAs have been recently identified as key regulatory RNAs with immense significance in numerous biological processes.They actively participate in the modulation of important cell physiological processes and are involved in the pathogenesis of asthma.MiRNAs have been implicated to have a fundamental role in acute and chronic asthma and in airway remodeling by the regulation of multiple signal transduction pathways that are involved in the pathogenesis of asthma.A better understanding of the role that miRNAs play in the diseases could lead to the development of new diagnostic and therapeutic tools.This review highlights the current understanding of the role and regulation of miRNA in asthma.
