Expression of β2 microglobin and vascular endothelial growth factors in diffuse large B-cell lymphoma and its clinical significance

VernacularTitle:蛋白芯片法检测弥漫大B细胞淋巴瘤患者血清β2微球蛋白和血管内皮生长因子蛋白表达的临床意义
Author: Jianzhong WU ; Yuejiao ZHONG ; Rong MA ; Haixia CAO ; Zhuo WANG ; Changwen JING ; Jifeng FENG
Publication Type:Journal Article
Keywords: Lymphoma,large B-cell,diffuse; Vascular endothelial growth factors; β2 microglobulin
From: Cancer Research and Clinic 2013;25(10):678-680
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression and clinical significance of β2 microglobin (β2-MG)protien and vascular endothelial growth factor (VEGF) protien in diffuse large B-cell lymphoma (DLBCL).Methods The expressions of VEGF protien and β2-MG protien were evaluated in 49 DLBCL patients which started the initial treatment by luminex suspension array.Results Among 49 DLBCL patients,expression of β2-MG protein was high in 37 cases and the expression of VEGF protein was high in 23 cases.The expression of VEGF protien and β2-MG protien were not related with gender,age,B symptoms,clinical stage and lactic acid (LDH).There was positive correlation between the high expression of β2-MG protien and chemotherapy (P =0.037).There was relevant trend between the higher expression of VEGF protien (P =0.067).Conclusion The expressions of VEGF protien and β2-MG protien are detected in DLBCL,both proteins may be the potencial markers of DLBCL and therapeutic targets for DLBCL.