Association Between IL-13 Polymorphism (-1512A/C) and Atopic Dermatitis in Korean Children.
- Author:
Kyung Won KIM
1
;
Mi Jin KANG
;
Hyo Bin KIM
;
So Yeon LEE
;
Nam Chul KIM
;
Seong Ok JANG
;
Soo Jong HONG
Author Information
1. Busan Science Academy, Korea.
- Publication Type:Original Article
- Keywords:
Atopic dermatitis;
Interleukin-13;
Promoter;
Polymorphism
- MeSH:
Alleles;
Asthma;
Child*;
Dermatitis, Atopic*;
Eosinophils;
Gene Frequency;
Genotype;
Humans;
Immunoglobulin E;
Immunoglobulins;
Interleukin-13*;
Interleukins;
Phenotype;
Polymorphism, Single Nucleotide;
Promoter Regions, Genetic
- From:Pediatric Allergy and Respiratory Disease
2005;15(2):126-132
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Interleukin (IL) -13 plays a pivotal role in the induction of immunoglobulin E (IgE) and in the pathogenesis of atopic dermatitis (AD). Recently, an association was reported between the polymorphism of the IL-13 promoter region (-1512A/C) and atopic asthma. We investigated the association between the IL-13 single nucleotide polymorphism (SNP) in the promoter region (-1512A/C) and atopic dermatitis in Korean children with AD. METHODS: We enrolled 204 allergic AD, 92 non-allergic AD, and 116 non-atopic healthy children. Evaluated phenotypes of atopic dermatitis included total IgE, total eosinophil count, and eosinophil fraction. We used a PCR-RFLP method to identify IL-13 genotypes. RESULTS: The allele frequencies of the IL-13 promoter polymorphism (-1512A/C) did not differ statistically among the three groups. Children with one or two copies of risk alleles in the promoter region (-1512C) did not show any significant association with the clinical phenotypes of atopic dermatitis including total IgE, eosinophil phenotypes and SCORAD score in the allergic or non-allergic atopic dermatitis. CONCLUSION: These data suggest that the -1512A/C polymorphism of IL-13 gene may not be associated with neither the development nor the clinical phenotypes of atopic dermatitis in Korean children.
