Cut-off values of amino-terminal pro-B-type natriuretic peptide for the diagnosis of chronic heart failure in children of age stratification with congenital heart disease prior to heart surgery
10.3760/cma.j.issn.1673-4408.2013.06.026
- VernacularTitle:先天性心脏病患儿术前充血性心力衰竭年龄分层后血浆氨基末端B型脑利钠肽前体诊断界值的研究
- Author:
Chunwang LIN
;
Xianglin ZENG
;
Xiuhui MENG
;
Shaohu JIANG
;
Hui OUYANG
- Publication Type:Journal Article
- Keywords:
Congenital heart disease;
Congestive heart failure;
Amino-terminal pro-B-type natriuretic peptide;
Cut-off value;
Children
- From:
International Journal of Pediatrics
2013;40(6):632-634
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the plasma amino-terminal pro-B-type natriuretic peptide (NT-ProBNP) of children with congenital heart disease(CHD) prior to heart surgery,to analysize its sensitivity,specificity and Youden index by receiver operating characteristic(ROC) curve,to explore the cut-off values of plasma NTProBNP for the diagnosis of congestive heart failure(CHF) in children under 5 years old before and after age stratification.Method The plasma NT-proBNP was detected for 100 children with CHD prior to heart surgery (experimental group) and 100 normal children(control group) between January 2011 to January 2013.Age stratification(0 ～ 1 year group,～3 years group and ～ 5 year group) was conducted in children with CHF younger than 5 years old to explore the cut-off values of plasma NT-ProBNP for the diagnosis of CHF.Results The NT-proBNP of 34 patients with CHF(n =100) was in accordance to Ross criteria The cut-off values were 502 ng/ L before age stratification,and they were 552 ng/L,449 ng/L,349 ng/L after age stratification for 0 ～ 1 year group,～ 3 years group and ～ 5 group.Conclusion The cut-off values of plasma NT-ProBNP for CHF were 552 ng/L、449 ng/L、349 ng/L for 0 ～ 1 year group,～ 3 years group and ～ 5 year group.
