Progress of research in the regulatory mechanism of enterovirus 71 in host immune response
10.3760/cma.j.issn.1673-4408.2013.06.021
- VernacularTitle:肠道病毒71型调控宿主免疫反应机制的研究进展
- Author:
Chuanzhen CHI
;
Qiyu SUN
- Publication Type:Journal Article
- Keywords:
Enterovirus 71;
Host immune;
Cytokines;
Apoptosis
- From:
International Journal of Pediatrics
2013;40(6):613-616
- CountryChina
- Language:Chinese
-
Abstract:
Virus infection can cause a variety of host immune response to prevent the spreading of virus.Innate immunity is the first line of defense to resist to virus infection in host.After the virus enters,the macrophage phagocytoses and process of virus antigen.On the other hand,it activates the innate antiviral immune response.The expression of interferon after EV71 infection may be associated with cell specific response.Most studies have shown that EV71 can inhibit the expression of interferon to achieve immune escape.Then antigen presenting cells present antigens to T/B lymphocytes,once specific T/B lymphocytes are activated by antigen,they will be activated,proliferated,diferentiated to immunologic effector cells,which secrete antibodies,cytokines,cell toxicity of medium,ultimately,develop immunological effect.Both humoral immunity and cellular immunity are activated in EV71 infection,and play an important role in mediating protection effect.Cellular immunity may be associated with the clinical outcome of EV71 infection.The EV71-specific neutralizing antibody generated by the humoral immunity plays a key role in protective immunity,but the antibody response level is not correlated with disease severity.In addition,virus infection can induce cell apoptosis to prevent the virus proliferation and the spreading of progeny virus.
