Lead exposure influence on children's bone mineral density
10.3760/cma.j.issn.1673-4408.2013.06.020
- VernacularTitle:儿童铅暴露对骨密度影响的研究进展
- Author:
Guixia CHEN
;
Huiling FENG
- Publication Type:Journal Article
- Keywords:
Children;
Lead exposure;
Source;
Toxic effect;
Bone mineral density
- From:
International Journal of Pediatrics
2013;40(6):610-612
- CountryChina
- Language:Chinese
-
Abstract:
Lead exposure is toxic to children.With the development of industry,lead exposure of children becomes more and more serious.Bone is the major target organ for lead loading.In terms of bone development,childhood is a critical period for the production of peak bone mass,and keeping it normal is important for the measurement of bone health and decreasing the morbidity of osteoporosis.Recent research revealed that children's bone mineral density is affected by elevated level of blood lead and this effect is mainly through the inhibition of the activity of osteoblast cell,the influence on calcium and phosphorus metabolism,and the retardation of children's bone growth.Therefore,the review focuses on the source,toxic effect,and the influence on bone mineral density and its mechanism of children lead exposure.
