The relationship of convulsion related brain damage and cell autophagy
10.3760/cma.j.issn.1673-4408.2013.05.014
- VernacularTitle:惊厥性脑损伤与细胞自噬的相关性
- Author:
Na ZHAO
- Publication Type:Journal Article
- Keywords:
Autophagy;
Convulsions;
Brain damage;
Association
- From:
International Journal of Pediatrics
2013;40(5):485-488
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is a lysosomal degradation of intracellular material composition,and plays an important role in nerve cell survival and clear senescent cells and misfolded proteins.Autophagy can protect nerve cells,but also can be used as one of the ways about nerve death.Repeated seizures can cause brain damage,but the specific mechanism is not clear.Recent studies have shown that,convulsion can activate apoptosis pathway and start autophagy,which can mediate the adaptation,injury or apoptosis of neurons.Convulsion brain injury is closely related to cell autophagy.Autophagy as a new important signaling pathway can provide a new therapeutic direction of convulsion brain damage.
