Advances of neonatal hypoglycemia and hypoglycemic brain damage
10.3760/cma.j.issn.1673-4408.2013.05.012
- VernacularTitle:新生儿低血糖及低血糖性脑损伤的研究进展
- Author:
Li ZHANG
;
Xiangfan ZHEN
- Publication Type:Journal Article
- Keywords:
Neonate;
Hypoglycemia;
Brain damage;
Energy metabolism
- From:
International Journal of Pediatrics
2013;40(5):477-480
- CountryChina
- Language:Chinese
-
Abstract:
Hypoglycemia is a common and early metabolic disease of neonate.Serious and persistent hypoglycemia could result in brain damage.So far the pathogenesis of the disease is on research,but the definition of hypoglycemia,the glucose threshold of intervention,and diagnostic criteria of brain damage are still unclear.The pathogenesis of hypoglycemia is complicated.Brain damage may be related to the specific excitory amino acids receptors,reduced blood flow in occipital lobe,and cerebral hypoxia and ischemia.Diffusion weighted imaging of brain MRI and magnetic resonance spectroscopy are strongly recommended for the diagnosis of brain damage.Besides,clinical manifestation and cerebral function monitor are also included in the diagnosis.The threshold of intervention is suggested as serum glucose concentration with 2.2 ～ 2.6 mmol/L.
