The progress of Olig genes and diseases of central nervous system
10.3760/cma.j.issn.1673-4408.2013.05.011
- VernacularTitle:Olig基因与中枢神经系统疾病的研究进展
- Author:
Tongfei CHENG
- Publication Type:Journal Article
- Keywords:
Oligl;
Olig2;
Oligodendrocyte;
Myelin;
Diseases of central nervous system
- From:
International Journal of Pediatrics
2013;40(5):474-476
- CountryChina
- Language:Chinese
-
Abstract:
Oligl and Olig2 are Olig family major members.Recent studies have found that Oligl and Olig2 are closely related to many diseases of central nervous system,such as demyelinating diseases,gliomas and hypoxia-ischemia brain injury.They are not only involved in the directed differentiation of precursor oligodendrocyte and stranscriptional regulation of the maturation of oligodendrocytes,but also play vital roles in the development of the central nervous system and the formation of myelin.Therefore,the research about the relationship of Olig genes and central nervous system diseases have been focused at home and abroad.
