The importance of histone acetylation modification in children's asthma and corticoid therapy
10.3760/cma.j.issn.1673-4408.2013.05.003
- VernacularTitle:组蛋白乙酰化修饰在儿童哮喘中的作用及糖皮质激素治疗
- Author:
Zhenzhen PAN
- Publication Type:Journal Article
- Keywords:
Asthma;
Acetylation modification;
Children;
Corsticord
- From:
International Journal of Pediatrics
2013;40(5):443-446
- CountryChina
- Language:Chinese
-
Abstract:
The incidence of bronchial asthma in children is increasing nowadays.More and more studies have showed that epigenetics plays an important role in the pathogenesis of asthma.One of them are histone modification(acetylation and deacetylation),which is catalyzed by histone acetyltransferase (HAT) and histone deacetylase (HDAC).HAT and HDAC can mediate asthma via causing Th1/Th2 imbalance,increased airway hyperresponsiveness,regulation of various inflammatory medium and so on.This paper reviews the HAT and HDAC mediated incidence of asthma and other possible mechanisms,the latest of glucocorticoid in the treatment of children with asthma epigenetic mechanisms.
