Study of serum LOX-1 and lipids in patients with obstructive sleep apnea hypopnea syndrome
10.3760/cma.j.issn.1671-7368.2013.10.016
- VernacularTitle:阻塞性睡眠呼吸暂停低通气综合征患者植物凝集素样氧化低密度脂蛋白受体-1及血脂水平的研究
- Author:
Yan LI
;
Xiuhong NIE
;
Wei ZHANG
;
Xiaojun FAN
;
Kui REN
;
Shang GAO
- Publication Type:Journal Article
- Keywords:
Sleep apnea,obstructive;
Receptors LDL;
Dyslipidemias
- From:
Chinese Journal of General Practitioners
2013;12(10):816-819
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of serum lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) and the level of lipids in patients with obstructive sleep apnea hypopnea syndrome (OSAHS).Methods A total of 94 candidates with sleep disorders between January-July 2011 at outpatient department were monitored with polysomnography.According to apnea-hypopnea index (AHI),they were divided into mild-to-moderate OSAHS (5 ≤ AHI ≤ 30) (n =27),severe OSAHS (AHI ＞ 30) (n =37) and normal control groups (AHI ＜ 5) (n =30).After polysomnography,their blood samples were obtained to measure the levels of serum LOX-1,triglycerides (TG),cholesterol (TC),high-density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C).Results The serum level of LOX-1 in severe OSAHS group was significantly higher than that in the mild-to-moderate and control groups (P ＜ 0.01).The serum level of LOX-1 in OSAHS patients was positively correlated with AHI and longest apnea time (LAT)(r =0.645 & 0.501 respectively,both P ＜ 0.01) and was negatively correlated with SaO2 (r =-0.647,P ＜0.01).No significant difference existed in serum lipids in all groups (P ＞ 0.05).Conclusions Intermittent hypoxia caused by OSAHS increases the level of LOX-1 to further promote the formation and development of atherosclerotic in patients with OSAHS.The levels of lipid can not effectively predict the severity of lipid metabolism disorder in patients with OSAHS.
