5-Fu concentration in splanchnic and peripheral blood, peritoneal fluid and carcinoma tissues after intraoperative regional arterial perfusion chemotherapy in patients of gastric antrum cancer
10.3760/cma.j.issn.1007-631X.2013.10.008
- VernacularTitle:胃窦癌术中区域动脉灌注化疗后门静脉血、周围静脉血、腹腔渗液及癌组织中药物浓度的测定
- Author:
Shusen XIA
;
Chongshu WANG
;
Caiquan ZHANG
;
Jiang DU
;
Shoujiang WEI
;
Jiangwei XIAO
;
Guangjun ZHANG
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Chemotherapy,cancer,regional perfusion
- From:
Chinese Journal of General Surgery
2013;28(10):748-750
- CountryChina
- Language:Chinese
-
Abstract:
Objective To measure 5Fu concentration after intraoperative regional arterial perfusion chemotherapy in gastric antrum cancer patients.Method In this study,32 gastric antrum cancer patients intraoperatively received through right gastroepiploic artery intraarterial perfusion of 5-Fu (1000 mg/m2),and drug conentrations were measured in portal venous blood,peripheral venous blood,peritoneal fluid and in removed cancer tissues 2,5,10,20,30,60 minutes after infusion started by high performance liquid chromatography method.Result 5-Fu in portal vein blood and peritoneal fluid reached peak concentration after 2 minutes at (48.8 ±6.8) μg1/ml and (75.3 ±30.7) μg/ml,respectively.The drug concentration in portal venous blood was (19.2 ± 2.0) μg/ml at 30 minutes and that in peritoneal fluid was (17.3 ±7.4) μg/ml at 60 minutes,both were higher than that of the effective experimental tumor suppressing concentration (15 μg/ml).Peripheral venous blood concentration reached peak concentration of (5.4 ± 2.0) μg/ml at 5 minute.The drug concentration in removed cancer tissues was (80.5 ± 20.1) μg,/ml.Conclusions Regional intraarterial perfusion chemotherapeutics in gastric antrum cancer patients during operation immediately makes the concentration of chemotherapy rise in the portal vein blood and peritoneal fluid and in cancer tissues to a much higher level than that in peripheral blood.This helps kill cancer cells that fell out during the surgery.
