Preoperative systemic chemotherapy plus regional intraarterial chemoembolization for patients with locally advanced gastric cancer
10.3760/cma.j.issn.1007-631X.2013.10.003
- VernacularTitle:局部进展期胃癌术前全身静脉联合区域动脉灌注化疗栓塞的疗效评价
- Author:
Yongshun GAO
;
Guowu QIAN
;
Yunfei ZHANG
;
Gang WU
;
Wencai LI
;
Wugan ZHAO
;
Yangyang ZHAO
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Chemotherapy,cancer,regional perfusion;
Chemotherapy,adjuvant
- From:
Chinese Journal of General Surgery
2013;28(10):736-739
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy and safety of preoperative systemic chemotherapy combined with regional intraarterial chemoembolization in the treatment of locally advanced gastric cancer.Methods Clinical data of 158 patients of locally advanced gastric receiving neoadjuvant chemotherapy cancer from January 2008 to July 2012 were retrospectively analyzed.Patients were divided into two groups:those who received preoperative systemic chemotherapy plus regional intraarterial chemoembolization (group A,n =78) and those who received preoperative systemic chemotherapy (group B,n =80).Radical resection was perfomed after 3 to 4 weeks.Results The overall satisfactory rate was significantly higher (60％) in group A compared with 42％ in group B (x2 =6.136,P ＜0.05).The incidence rate of toxicity reaction (except nausea) and postoperative conplications such as anastomotic leakage,intestinal obstruction,poor wound healing,abdominal infection and pulmonary infection were all lower in group A than in group B (all P ＜ 0.05),while the incidence rate of nausea was higher in group A than in Group B (x2 =16.458,P ＜ 0.01).There was no perioperative mortality related to neoadjuvant therapy in two groups.Conclusions Preoperative systemic chemotherapy combined with regional intraarterial chemoembolization was associated with better efficacy,and fewer toxicity reactions and postoperative complications in the treatment of locally advanced gastric cancer.
