Clinicopathological characteristics and prognosis of patients of serum alpha-fetoprotein-producing gastric cancer
10.3760/cma.j.issn.1007-631X.2013.10.005
- VernacularTitle:血清AFP阳性胃癌患者的临床病理及预后
- Author:
Peng ZHOU
;
Hui QU
;
Guorui SUN
;
Qingsi HE
;
Yang XU
;
Jingwei PENG
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Alpha-fetoproteins;
Pathology,clinical;
Prognosis
- From:
Chinese Journal of General Surgery
2013;28(10):740-743
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinicopathological characteristics and prognosis of serumb alpha-fetoprotein(AFP)-producing gastric cancer.Methods A total of 1396 cases of gastric cancer in our hospital from 2002 to 2007 were retrospectively reviewed.The relationship between serum AFP with clinicopathological factors,survival rate,prognosis and liver metastasis were analyzed.Results There were 90 AFP-producing gastric cancer patients accounting for 6.45％ of all the gastric cancer cases during the time period.In those patients there was bigger tumor size,more T3 and T4 invasion (82.2％ vs.69.2％),higher incidence of lymph node metastasis (80.0％ vs.60.2％)and liver metastasis(6.67％ vs.1.68％),and later clinical stage than that in the AFP-negative group.The 1,3,5 year-overall survival (OS) rate in AFP-positive group were 52.2％,31.1％,20％ while those in AFP-negative group were 82.5％,59.9％,48.8％.The 1,3,5 year-disease free survival(DFS) rate in AFP-positive group were 47.8％,24.4％,15.6％ while those in AFP-negative group were 77.5％,54.8％,44.3％.The AFP-positive group had a shorter median time period than the AFP-negative group when liver metastasis happened (5 months vs.11 months).Conclusions Serum AFP-producing gastric cancer was higher malignancy,it was deeper in invasion and later in clinical stage,more patients with lymph nodes and liver metastasis,low survival rate and poorer prognosis.
