Effects of different types of acute respiratory distress syndrome on high frequency oscillatory ventilation-improved extravascular lung water and pulmonary vascular permeability in piglets
10.3760/cma.j.issn.0254-1416.2013.09.031
- VernacularTitle:不同类型ARDS对高频振荡通气改善幼猪血管外肺水和肺血管通透性效应的影响
- Author:
Qiujie LI
;
Yin YUAN
;
Yumei LI
;
Leying SUN
;
Shiying YUAN
- Publication Type:Journal Article
- Keywords:
Respiratory distress syndrome,adult;
High-frequency ventilation;
Extravascular lung water;
Capillary permeability;
Lung
- From:
Chinese Journal of Anesthesiology
2013;33(9):1142-1144
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of different types of acute respiratory distress syndrome (ARDS) on high frequency oscillatory ventilation (HFOV)-improved extravascular lung water and pulmonary vascular permeability in piglets.Methods Twelve healthy piglets,weighing 15-20 kg,were randomly allocated into 2 groups (n =6 each) using a random number table:endogenous ARDS (P group) and exogenous ARDS (EXP group).Anesthesia was induced with midazolam and propofol.The tracheal tube was inserted.Anesthesia was maintained with iv infusion of propofol and fentanyl.ARDS was induced with normal saline infused via the tracheal tube in group P.ARDS was induced with oleic acid 0.05 ml/kg injected intravenously over 45-60 min in group EXP.Then 4 h of HFOV was performed.Before ARDS (T0),immediately after ARDS (Ti) and at 1,2,3 and 4 h of HFOV (T2-5),arterial blood samples were collected for blood gas analysis and the variables such as extravascular lung water index (EVLWI),pulmonary vascular permeability index (PVPI),and extravascular lung water (EVLW)/intra thoracic blood volume (ITBV) were monitored.The oxygenation index (PaO2/FiO2) was calculated.Results Compared with the baseline value at T0,the oxygenation index was decreased at T1,and the oxygenation index was less than 200 mm Hg in the two groups (P ＜ 0.05).There was no significant difference in the maximum degree of changes in EVLWI,PVPI and EVLW/ITBV between the two groups (P ＞ 0.05).Conclusion Endogenous and exogenous ARDS disease factor does not affect HFOV-improved extravascular lung water and pulmonary vascular permeability in piglets.
