Evaluation of Cardioprotective Effects of DelNido Cardioplegia.
- Author:
Seok Jeoung WOO
;
Bong Hyun CHANG
;
Kyu Tae KIM
- Publication Type:Original Article
- MeSH:
Animals;
Cardioplegic Solutions;
Creatine;
Heart;
Heart Arrest, Induced*;
Heart Rate;
Magnesium;
Mannitol;
Plasma;
Rats;
Water
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
2000;33(8):613-622
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The aim of this study is to define the cardioprotective effects (functional and metabolic) of newly developed DelNido cardioplegic solution (containing plasma solution, mannitol, magnesium and lidocaine). MATERIAL AND METHOD: This study assessed the function of rat hearts after itermittent infusion of DelNido cardioplegia with different preserving methods(Air or Icebox) for 2hours and perfusing the hearts on a Langendorff apparatus. Heart rate, left ventricular developed pressure (LVDP) and coronary flow, were measured at pre-ischemic, post-reperfusion 15min, 30min and 45min. Coronary flow was standardized to dry heart weight. Each weight was weighted to calculate water content. Creatine kinase-MB isoenzyme release was measured and ultrastructural assessment was done with electron microscopes. DelNido group was better than St, Thomas group and Icebox group was better than Room-air group. CONCLUSION: DelNido cardioplegia have better myocardial protective effects than St. Thomas cardioplegia when they were preserved in the Room-air. But we can not tell the difference between Delnido cardiplegia with Air preserving method and St. Thomas cardioplegia with Icebox.
