The study on the expression of interleukin-17 and receptor activator of nuclear factors κB-ligand in serum of patients with ankylosing spondylitis
10.3760/cma.j.issn.1007-7480.2013.11.011
- VernacularTitle:白细胞介素-17与细胞核因子-κB受体活化因子配体在强直性脊柱炎患者血清中表达的研究
- Author:
Xiujuan LI
;
Shengqi HUANG
;
Ani WANG
;
Hui ZHENG
;
Shiying LI
;
Weiguang CHEN
;
Feng WEI
- Publication Type:Journal Article
- Keywords:
Spondylitis,ankylosing;
Interleukin-17;
Receptor activator of nuclear factor κB-ligand;
Osteoprotegerin
- From:
Chinese Journal of Rheumatology
2013;17(11):769-771
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role and value of interleukin (IL)-17,receptor activator of nuclear factors κB-ligand (RANKL),osteoprotegerin (OPG) in the pathogenesis of AS by detecting the expression of IL-17,RANKL,OPG.Methods IL-17,RANKL,OPG in 44 AS and 15 healthy controls were measured by ELISA.HLA-B27 was measured by flow cytometry.T-test,Spearman's correlation analysis were used for statisical analysis.Results ① Serum IL-17 [(45±12) pg/ml],RANKL [(354±96) pg/ml] levels and RANKL/OPG [(6.5±3.4) pg/ml] ratio were significantly higher in AS patients than those in normal controls (t=11.18,P＜0.05; t=18.66,P＜0.05; t=15.48,P＜0.05),and the serum RANKL levels was higher in AS patients in middle and late period than that in AS patients in early stage (t=47.02,P＜0.05).The serum OPG levels was higher in AS patients in middle and late period than that in AS patients in early stage (t=15.48,P＜0.05).② There were positive linea correletion,respectively,between the serum levels of IL-17 and RANKL (r=0.532,P=O.021),and between serum levels of IL-17 and disease activities of BASDAI (r=0.625,P=0.023),between serum levels of RAN KL and disease activities of BASDAI (r=0.431,P=0.016).Conclusion The surem levels of IL-17 and RANKL are increased in AS patient.
