Association of TLR4 gene polymorphisms with susceptibility to primary gouty arthritis in Chinese Han population
10.3760/cma.j.issn.1007-7480.2013.11.002
- VernacularTitle:Toll样受体4基因单核苷酸多态性与我国汉族人群原发性痛风性关节炎发病的相关性研究
- Author:
Yufeng QING
;
Jingguo ZHOU
;
Quanbo ZHANG
;
Min LI
;
Cuiping HUANG
;
Ling YING
- Publication Type:Journal Article
- Keywords:
Polymorphism,single nucleotide;
Arthritis,gouty;
TLR4
- From:
Chinese Journal of Rheumatology
2013;17(11):724-728
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of TLR4 gene polymorphisms with susceptibility to primary gouty arthritis (GA) in Chinese Han population.Methods A total of 459 patients with GA and 459 healthy control subjects were enrolled into this study.All the genotyping assays of TLR4 gene polymorphisms loci [rs4986790 (Asp299Gly),rs4986791 (Thr399Ile),rs2 1 49356T＞G] were measured using TaqMan probes that specifically target the alternate alleles.Results All the subjects were found to be homozygous for the wild-type TLR4 alleles (Asp/Asp,Thr/Thr) on TLR4 Asp299Gly and Thr399Ile genotyping.There was no significant deviation from HWE both in GA and controlsin the rs2149356 (x2=0.778,1.295; P＞0.05,respectively).Significant differences were observed between the GA and control groups with respect to genotype and allele frequencies of TLR4 gene rs2149356 (x2=16.23,17.08; P＜0.01,respectively),and TT genotype was the risk factor for gout (adjusted OR=2.09).Conclusion The TLR4 gene rs2149356 SNP may be associated with GA susceptibility,and TT genotype may be the risk factor for developing gout.
