Expression of Paxillin and carbonic anhydrase Ⅸ in patients with the duodenal papillary carcinoma
10.3760/cma.j.issn.1008-6315.2013.11.002
- VernacularTitle:桩蛋白与碳酸酐酶Ⅸ在十二指肠乳头癌组织中的表达及意义
- Author:
Lin TIAN
;
Hong YANG
;
Peiyi ZHANG
;
Lihua HU
;
Jiye ZHANG
- Publication Type:Journal Article
- Keywords:
Pile protein;
Carbonic anhydrase Ⅸ;
Duodenal papilla carcinoma
- From:
Clinical Medicine of China
2013;29(11):1124-1126
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the pile protein (paxillin) and carbonic anhydrases Ⅸ (CA Ⅸ)expression and its significance in duodenal papilla carcinoma patients.Methods Eighty-seven cases of duodenal papilla carcinoma were enrolled as our subject.Immunohistochemical staining was used to detect the expressions of paxillin and CAⅨ in site of tumor,adjacent tissue and duodenal papillitis tissue.Results Sixtyfive cases (74.7％ (65/87)) were showed a higher expression of paxillin in cancer site than that of adjacent tissue (41％ (16/39),P ＜ 0.05) and duodenal papillitis tissue (41.3％ (19/46),P ＜ 0.05),and the difference was statisically significant (x2 =19.869,P ＜0.05).While a higher expression of CA Ⅸ in 62 cases (71.3％) in cancer site was seen,higher than that of adjacent tissue (33.3％ (13/39),P ＜ 0.05) and duodenal papillitis tissue (30.4％ (14/46),P ＜ 0.05),and the difference was statisically significant (x2 =26.936,P ＜ 0.05).As the increase of the cancer tissue malignant degree and the surrounding tissue invasion or distant metastasis degree,paxillin and CA Ⅸ expression increased.Conclusion The paxillin and CAⅨ might served as the early indicators for diagnosis and judgment of prognosis of duodenal papilla cancer.
