Expression and its clinical significance of adisintegrin and metalloprotease-17 in human glioma

VernacularTitle:解聚素-金属蛋白酶在人脑胶质瘤的表达及其临床意义
Author: Yan ZHANG ; Suqin ZHENG ; Xuepeng ZHANG ; Jinlu LI ; Jing SONG
Publication Type:Journal Article
Keywords: Glioma; Adisintegrin and metalloprotease-17; Immunohistochemistal staining
From: Clinical Medicine of China 2013;29(11):1121-1123
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression and its clinical significance of adisintegrin and metalloprotease-17 (ADAM17) in human glioma.Methods The expressions of ADAM17 in human glioma were detected by immunohistochemical staining.The correlation between ADAM17 expression and the malignance of glioma was analyzed.Results Expression of ADAM17 in human gliomas increased.With the malignant degree,ADAM17 expression has also further increased.However,there was a less ADAM17 expression in normal human brain.The positive expression of ADAM17 in low malignant group was 75％ (18/24),of which 1 case were strong positive.The strong positive expression of ADAM17 was the majority (82.1％,23/28) in malignant group.Conclusion The expression of ADAM-17 was higher in human brain gliomas.With malignance degree increased,of the ADAM-17 expression has gradually increased,suggesting that ADAM-17 might play a certain role in the occurrence and development of glioma.