Comparative study on negative symptoms of schizophrenia treated with amisulpride and other second-generation antipsychotics: a meta-analysis
10.3760/cma.j.issn.1674-6554.2013.09.020
- VernacularTitle:氨磺必利治疗精神分裂症阴性症状的疗效与安全性Meta分析
- Author:
Feng YI
;
Xingyan JIANG
;
Xingfu ZHAO
;
Jingyu MAO
;
Lili ZHEN
- Publication Type:Journal Article
- Keywords:
Amisulpride;
Second-generation antipsychotics;
Schizophrenia;
Negative symptoms;
Meta-analysis
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2013;22(9):833-837
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the efficacy of amisulpride and other SGAs in treating the negative symptoms of Schizophrenia.Methods The randomized controlled trials (RCTs) about Schizophrenia treated with amisulpride and other SGAs from Jan 1995 to Mar 2013 were searched in The Pubmed,EMbase,Cochrane Library,WanFang Data,CNKI and VIP.Two reviewers independently screened the literatures,extracted the data,and evaluated the methodological quality.Than meta-analyses were conducted by using RevMan 5.1 and Stata 12.0 software.Results The totall3 RCTs were included.Among the 1814 patients involved.The results of meta-analyses showed that the score of PANSS-N was no significant differences between two groups (MD =-0.33,95％ CI:(-0.87,0.21),Z =1.20,P =0.23) ; and the score of SANS was no significant differences between two groups (MD =-0.21,95％ CI:(-1.51,1.50),Z =0.31,P =0.76).The side effects were more in other SGAs group than those in amisulpride group.Conclusion Amisulpride is as effective as other SGAs for the treatment of schizophrenia with predominantly negative symptoms,and it has more advantage than other SGAs in safety.
