The correlation of cognitive dysfunction with serum brain-derived neurotrophic factor level in depression patients
10.3760/cma.j.issn.1674-6554.2013.08.011
- VernacularTitle:抑郁症患者认知功能障碍与血浆脑源性神经营养因子水平的关系
- Author:
Yu FENG
;
Yuanyuan DAI
;
Zhiyin YANG
;
Feng JI
- Publication Type:Journal Article
- Keywords:
Depression;
Cognitive dysfunction;
Brain-derived neurotrophic factor
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2013;22(8):710-712
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the characteristics of cognitive dysfunction in patients with depression,and identify the correlation between cognitive dysfunction and serum brain-derived neurotrophic factor (BDNF) level.Methods All participants including 73 depressed patients and 71 healthy controls were received clinical and cognitive assessments at admission,the depression group was divided into two groups by the score of Beijing version of the Montreal Cognitive Assessment (MoCA-BJ),one was depression with cognitive dysfunction group which had 36 cases,the other was depression without cognitive dysfunction group which had 37 cases.Concentration of BDNF was measured by the ELISA method.Results Cognitive impairments were found in numerous cognitive domains of depressed patients,including visuospatial and executive abilities,attention,delayed recall and orientation(P ＜ 0.05).The incidence of cognitive dysfunction in depression was 49.3％.There was not significant difference between two depressive groups (depression with cognitive disorder(12.08 ± 7.08)ng/ml,depression without cognitive disorder (12.22 ± 7.93)ng/ml,P ＞ 0.05),and the levels were significantly lower than that in healthy people ((16.55 ± 7.47) ng/ml,P＜ 0.01),and serum BDNF level had no positively relevant with different cognitive functions (P ＞ 0.05).Conclusion Depression patients have cognitive dysfunction in numerous cognitive domains,including visuospatial and executive abilities,attention,delayed recall and orientation.Serum BDNF level is closely related with depression,while,it has no obvious relationship with cognition function in depression.
