Effects of Deanxit on depression and clinical outcomes in elderly patients with acute coronary syndrome

VernacularTitle:氟哌噻吨美利曲辛对老年急性冠脉综合症患者焦虑抑郁情绪及临床疗效的影响
Author: Guoliang YANG ; Jianjun WANG ; Lixin LIU ; Guanghe WEI ; Shaohui ZHANG ; Tiecheng WANG ; Ying GUO
Publication Type:Journal Article
Keywords: Deanxit; Acute coronary syndrome; Depression; Heart rate variability
From: Chinese Journal of Behavioral Medicine and Brain Science 2013;22(10):911-913
CountryChina
Language:Chinese
Abstract: Objective To investigate deanxit clinical efficacy of depression in elderly patients with acute coronary syndrome(ACS).Methods 88 elderly patients with ACS and depression were randomly divided into Deanxit (2 tablets daily ; Deanxit,n =43) or placebo (control,n =45) treatment in addition to standard therapy.SDA score,SDS score,MACE and cardiac autonomic nerve function were performed at 12 weeks follow-up.Results In deanxit group,SDA score and SDS score were significantly reduced (34.28 ± 6.35 vs 52.68 ± 5.74,41.19 ±4.63 vs 54.68 ± 4.32,P ＜ 0.05),MACE were also decreased (4.6％ vs 28.9 ％,P ＜ 0.05).SDNN were significantly higher than control (109.03 ± 23.08 vs 98.29 ± 27.44,P ＜ 0.05),but LF was reduced (152.89 ± 92.75vs 249.21 ± 64.17,P＜ 0.05).Conclusion Deanxit can improve the depression and clinical symptoms in elderly patients with ACS and depression.By improving the cardiac autonomic nerve function,deanxit possible reduce the onset of severe arrhythmia and improve the short-term prognosis.