The changes of brain-derived neurotrophic factor positive neurons and the morphology of pyramidal cells in hippocampal in sodium valproate induced autism rats

VernacularTitle:丙戊酸钠孤独症模型鼠海马脑源性神经营养因子阳性神经元表达及锥体细胞形态学的变化
Author: Mingji YI ; Xiaoxu MA ; Yin LI
Publication Type:Journal Article
Keywords: Autism spectrum disorder; Brain-derived neurotrophic factor; Pyramidal cell; Rats
From: Chinese Journal of Behavioral Medicine and Brain Science 2013;22(8):704-706
CountryChina
Language:Chinese
Abstract: Objective To explore the pathogenesis of autism by observation of changes of brain-derived neurotrophic factor(BDNF) positive neurons and the morphology of pyramidal cells in hippocampal CA1 region,and provide theoretical evidence for the therapeutic schedule.Methods Animal model of autism was obtained by Schneider method.Using the immunohistochemistry methods and image analysis,the number of BDNF positive neurons was examined in hippocampal CA1 region of the autism model rats and the normal rats,and the changes of pyramidal cell were observed in hippocampal CA1 region after HE staining.Results The numbers of BDNF positive neurons in the hippocampal CA1 region of the autism model rats were more than those of the normal rats (5.00 ±1.60 vs 3.00 ± 1.04,t =3.63,P =0.0015).The morphology of pyramidal cells showed that the pyramidal cells of the autism model rats in hippocampal CA1 region had apoptosis.Conclusion The occurrence of autism may be related to the changes of BDNF and the morphology of pyramidal cells in hippocampal CA1 region.