Effects of Serum 25-hydroxy-vitamin D and Fetal Bone Growth during Pregnancy.
10.11005/jbm.2015.22.3.127
- Author:
Dong Hyun LEE
1
;
Hyun Mee RYU
;
You Jung HAN
;
Si Won LEE
;
So Young PARK
;
Chang Hoon YIM
;
Sung Hoon KIM
;
Hyun Koo YOON
Author Information
1. Division of Endocrinoloy, Cheil General Hospital & Women's Healthcare Center, Dankook University College of Medicine, Seoul, Korea. hyunkooyoon@hotmail.com
- Publication Type:Original Article
- Keywords:
Fetal development;
Pregnancy;
Ultrasonography;
Vitamin D
- MeSH:
Bone Development*;
Female;
Femur;
Fetal Development;
Head;
Humans;
Humerus;
Pregnancy*;
Pregnant Women;
Prevalence;
Ultrasonography;
Ultrasonography, Prenatal;
Vitamin D;
Vitamin D Deficiency
- From:Journal of Bone Metabolism
2015;22(3):127-133
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: This study was conducted to observe the prevalence of vitamin D deficiency during pregnancy and the effects of maternal 25-hydroxy-vitamin D (25-[OH]D) levels on fetal bone growth. METHODS: Five hundred twenty-three Korean pregnant women were randomly recruited and serum 25-(OH)D level was measured. During pregnancy, fetal ultrasonography and serum 25-(OH)D measurements were carried out 3 times in 275 of 523 pregnant women. Fetal biparietal and occipitofrontal diameter, head and abdominal circumference, and femur and humerus length were measured through fetal ultrasonography. RESULTS: The prevalence of vitamin D deficiency (25-[OH]D<20 ng/mL) based on the 1st serum measurement of 25-(OH)D was 88.9%. There was no association between maternal serum 25-(OH)D level and fetal bone growth. In 275 pregnant women who completed study design, the mean value of 25-(OH)D was 12.97+/-5.93, 19.12+/-9.82, and 19.60+/-9.98 ng/mL at 12 to 14, 20 to 22, and 32 to 34 weeks of pregnancy, respectively and there was an association between the difference of serum 25-(OH)D level between 12 to 14 and 20 to 22 weeks and growth velocity of fetal biparietal diameter between 20 to 22 and 32 to 34 weeks of pregnancy. CONCLUSIONS: This study shows a high prevalence of vitamin D deficiency in Korean pregnant women and the change of serum 25-(OH)D levels is related with the growth of fetal biparietal diameter, however other parameters are not associated with serum 25-(OH)D levels.
