Roles of Pim-1 in tumors and related signaling pathways
10.3760/cma.j.issn.1673-422X.2013.10.001
- VernacularTitle:Pim-1在肿瘤及相关信号通路中的作用
- Author:
Zhijie LIANG
;
Miaomiao JIA
;
Bin ZHANG
;
Xuchen CAO
- Publication Type:Journal Article
- Keywords:
Proto-oncogene proteins c-pim-1;
Neoplasms;
Protein-serine-threonine kinases;
Signal transduction
- From:
Journal of International Oncology
2013;40(10):723-726
- CountryChina
- Language:Chinese
-
Abstract:
The overexpression of proto-oncogene protein c-pim-1 (Pim-1) in tumor tissue is related to the stage and prognosis.Recent studies indicate that Pim-1 plays a critical role in the proliferation and apoptosis of cells and the metastasis of tumor.Pim-1 acts as an essential factor in several signaling pathways and its expression and activation are regulated by many factors as well as affects others widely.As an influential factor in the occurrence and development of tumor,Pim-1 has been a potential target in oncotherapy.
