Expression of CXCR4 in breast cancer and the relationship between CXCR4 and Hedgehog signaling pathway

VernacularTitle:乳腺癌中CXCR4的表达及其与Hedgehog信号通路的相关性
Author: Shuangfei XU ; Jie WANG ; Zhigang ZHUANG
Publication Type:Journal Article
Keywords: Breast neoplasms; Receptors,chemokine; Receptors,CXCR4; Signal transduction
From: Journal of International Oncology 2013;40(9):711-714
CountryChina
Language:Chinese
Abstract: Objective To detect the expressions of CXCR4,Smoothened (Smo) and Patched (Ptch) in breast cancer,to analyze the clinical significance of the expression of CXCR4,and to evaluate the relationships among CXCR4,Smo and Ptch.Methods The expressions of CXCR4,Smo and Ptch from 121 cases of breast cancer specimens were detected by immunohistochemistry,and the results were analyzed.Results The positive expression rate of CXCR4 in breast cancer was 66.9％,which was positively associated with the lymph node metastasis (r =0.181,P =0.044).The positive expression rates of Smo and Ptch in breast cancer were respectively 58.9％ and 64.5％.The expressions of Smo and Ptch were positively associated with the expression of CXCR4 in breast cancer (r =0.189,P =0.036 ; r =0.230,P =0.010).Conclusion The expression of CXCR4 in breast cancer is associated with the lymph node metastasis,and it is positiviely associated with the expressions of Smo and Ptch.Patients with breast cancer who express both CXCR4 and Hedgehog signaling pathway may have a higher risk of recurrence.