Molecular targeted therapy for breast cancer patients based on Notch signal transduction pathway
10.3760/cma.j.issn.1673-422X.2013.09.012
- VernacularTitle:Notch信号转导通路与乳腺癌靶向治疗
- Author:
Yongqu ZHANG
;
Xiaowei DOU
;
Guojun ZHANG
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Notch signal transduction pathway;
Molecular targeted therapy
- From:
Journal of International Oncology
2013;40(9):678-680
- CountryChina
- Language:Chinese
-
Abstract:
Studies show that the Notch signal transduction pathway involves in the regulation and control of cell proliferation,differentiation and apoptosis.Aberrant Notch signaling transduction pathway can induce breast cancer in transgenic mice.High expressions of either Notch receptors or their ligands have been linked to poor prognosis in patients with breast cancer.Inhibition of Notch signal transduction pathway may be beneficial for breast cancer treatment.
