A Meta analysis of intra-arterial thrombolysis of recombinant tissue-plasminogen activator for treatment of acute cerebral infarction
10.3969/j.issn.1671-8348.2013.28.011
- VernacularTitle:重组组织型纤溶酶原激活剂动脉溶栓治疗急性脑梗死的Meta分析
- Author:
Xinggui LI
;
Liang CHEN
;
Yi KANG
;
Ge JIN
;
Xin LI
;
Rufang ZHANG
;
Qunling ZHAN
- Publication Type:Journal Article
- Keywords:
recombinant tissue plasminogen activator;
intra-arterial thrombolysis;
acute cerebral infarction;
Meta-analysis;
sys-tematic review
- From:
Chongqing Medicine
2013;(28):3363-3365
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of intra-arterial thrombolysis with recombinant tissue-plasminogen ac-tivator(rt-RA) for treatment of acute cerebral infarction (ACI) .Methods The randomized controlled trials (RCT ) of intra-arterial thrombolysis with rt-PA for treatment of ACI were selected from Cochrane Library ,Medline ,Embase and CBM by the computer re-trieval .A meta analysis of the data were analyzed by using RevMan 5 .1 software .Results A total of 473 patients in 9 selected RCTs were involved in the systematic review .Meta-analysis results disclosed suggested that the effectiveness of intra-arterial thrombolysis treated ACI group was better than that of intravenous thrombolysis group [RR= 1 .26 ,95% CI(1 .09 ,1 .45) ,P=0 .002] .No difference was observed between the two groups in intracranial hemorrhage and mortality rate .Conclusion The current evidence showed that ,the clinical effect of intra-arterial thrombolysis with rt-PA for treatment of ACI was obviously superior to that of intravenous thrombolysis ,but the result still needs to be confirmed by large-sample RCTs .
