The effects of venom peptide liquor on adjunctive arthritis in mice
10.3969/j.issn.1671-8348.2013.28.024
- VernacularTitle:蛇肽保健酒对小鼠佐剂性关节炎的影响
- Author:
Juanjuan CAO
;
Qiyi HE
;
Ying ZHAO
;
Rongchun ZHANG
;
Shirong WEI
;
Jiali ZOU
;
Kexuan DENG
;
Xiaodong YU
- Publication Type:Journal Article
- Keywords:
venom peptide liquor;
adjuvant arthritis;
spleen index;
swelling;
mice
- From:
Chongqing Medicine
2013;(28):3395-3397
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate effect of the venom peptide liquor on adjunctive arthritis (AA) in mice .Methods The male Kunming mice were randomly divided into 6 groups ,named as the control group ,model group ,positive control group(1 mg/kg dex-amethason) ,wine group(10 mL/kg) ,low dosage of venom peptide liquor group(8 .3 mL/kg) and high dosage of venom peptide liq-uor group(33 .2 mL/kg);the right toes ,ankle diameter and whole body weight were measured at 7-day intervals ;the spleen index , serum level of circulating immune complexes(CIC) were determined after the thirty-fourth day when the mice was put to death .Re-sults The level of CIC in AA mice decreased significantly (P<0 .05) ,the decrease of spleen index and the reduction of toe and an-kle swelling in the low dose group were significant(P<0 .01) .Conclusion The venom peptide liquor exhibited apparent inhibitory effect on AA in mice .
