Application of Fecal calprotectin in the clinical diagnosis of inflammatory bowel disease
10.3760/cma.j.issn.1008-1372.2013.08.004
- VernacularTitle:粪便钙卫蛋白在炎症性肠病中的临床诊断价值
- Author:
Xiaofang HAN
;
Yan TAN
;
Ruixia BAI
;
Yang LIU
;
Haiqin JIA
- Publication Type:Journal Article
- Keywords:
Leukocyte L1 antigen complex;
Feces;
Inflammatory bowel diseases/diagnosis;
Enzyme-linked immunosorbent assay
- From:
Journal of Chinese Physician
2013;15(8):1022-1024
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical application of fecal calprotectin in inflammatory bowel disease (IBD).Methods Colonoscopy took 79 patients with IBD that were diagnosed with pathology,including 47 cases of ulcerative colitis (UC) patients,32 cases of Crohn's disease (CD).Moreover,42 cases of IBD patients without abdominal pain,diarrhea and other intestinal inflammation were used as disease control group,and 34 cases of healthy people were used as healthy control group.The level of fecal calprotectin in each group was detected by enzyme-linked immunosorbent assay (ELISA).Results The positive rate of fecal Calprotectin in IBD group,disease control group and the healthy control group was 57.0％,19.0％,and 0,respectively; each positive rate in IBD group was significantly higher than the other two groups (P ＜ 0.05).The serum concentration of fecal calprotectin in IBD group [(493.86 ±204.18) μg/g] was significantly higher than the disease control group [(71.46 ± 60.51) μg/g] and the healthy control group [(36.19 ± 13.46) μg/g] (P ＜ 0.05) ; IBD active calprotection [(1015.23 ± 324.96) μg/g] was significantly higher than resting [(52.69 ±34.71) μg/g] (P ＜0.01).Conclusions Fecal calprotectin test benefits early diagnosis of IBD,and may be taken as the diagnostic index of IBD activity.It has extensively clinical value.
