Methylenetetrahydrofolate reductase polymorphism in three nationality in Guizhou
10.3969/j.issn.1671-8348.2013.28.031
- VernacularTitle:贵州3个民族亚甲基四氢叶酸还原酶基因的遗传多态性
- Author:
Ting ZHANG
;
Yuan XIE
;
Yi LI
;
Keren SHAN
;
Zhizhong GUAN
- Publication Type:Journal Article
- Keywords:
methylenetetrahydrofolate reductase;
polymorphism;
minority groups
- From:
Chongqing Medicine
2013;(28):3413-3415
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify the distribution feature of methylenetetrahydrofolate reductase (M T HFR) gene polymorphism of Buyi ,Dong ,Miao nationality in Guizhou .Methods The MTHFR(677 and 1 298) genotypes of Buyi ,Miao and Dong healthy indi-viduals were determined by TaqMan-MGB probe genotyping method and constructed haplotypes .Results There were significant difference of MTHFR 677C/T genotype and allele frequencies among 3 groups(P<0 .05) ,There was significant difference of geno-type between Buyi and Miao nationality ,and there were significant differences of genotype frequencies in Buyi nationality and Dong and Miao nationality(P<0 .01) .There were no differences of MTHFR 1298A/C genotype frequencies among Buyi ,Dong and Miao nationality(P> 0 .05) .Buyi nationality had the lowest frequency in double wild homozygous type (677CC/1298AA) ,677TT/1298CC double mutation homozygous and 677TT/1298AC combination in above three minorities was not found .There were linkage disequilibrium between 677C/T and 1298A/C in Buyi and Miao nationality .Conclusion The genotypes frequencies of MTHFR 677T T/1298AC are significant differences among different regions and different ethnic groups .
