Stem cells in cartilage tissue engineering and influential factors
10.3969/j.issn.2095-4344.2013.46.022
- VernacularTitle:干细胞在软骨组织工程中的应用及其影响因素
- Author:
Yan WANG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2013;(46):8116-8121
- CountryChina
- Language:Chinese
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Abstract:
BACKGROUND:A variety of stem cells as seed cells for cartilage tissue engineering have been extensively studied.
OBJECTIVE:To analyze the biological characteristics of different kinds of stem cells and their application in cartilage tissue engineering.
METHODS:By retrieving recent studies on sources of stem cells and influential factors in cartilage tissue engineering, the authors focused on optimization of harvesting stem cells from different sources in bone tissue engineering, problems, and factors that affect cellgrowth, differentiation, reproduction and metabolism, which provide a theoretical basis for tissue-engineered cartilage repair.
RESULTS AND CONCLUSION:A large number of experimental studies have confirmed that exogenous stem cells can be used as seed cells for cartilage tissue engineering. Influential factors relative to cartilage tissue engineering construction using seed cells include growth factors, cellscaffold, cellseeding density, oxygen concentration, stress and micro-gravity. However, tissue-engineered cartilage is stil in the stage of laboratory research, and stem cells for cartilage tissue engineering involves many issues, such as stem celltransformation, in vitro culture of stem cells, how to prolong the survival of cells, reduce cellantigenicity and enhance the host’s immune tolerance, which are yet to be resolved.
