Expression and significance of interleukin-25 level in airway inflammation of asthmatics

VernacularTitle:IL-25在支气管哮喘患者气道炎症中的表达及临床意义
Author: Hongjia LI ; Fen LIU ; Degan LU ; Yinghua SONG ; Chao WANG ; Caiqing ZHANG
Publication Type:Journal Article
Keywords: Asthma; Interleukin-25
From: Chinese Journal of General Practitioners 2013;12(11):913-915
CountryChina
Language:Chinese
Abstract: A total of 59 untreated asthmatics and 47 healthy control subjects were recruited from Qianfoshan Hospital of Shandong Province from May 2011 to April 2012.Compared with healthy control subjects,the levels of IL-25 in induced sputum and eosinophils,IgE,interleukin-4 (IL-4) and interleukin25 (IL-25) in serum samples of asthmatics were significantly higher while the level of interferon-gamma (IFN-γ) were much lower.However,after inhaled glucocorticoid treatment,the levels of eosinophils,IL-4 and IL-25 decreased and IFN-γ significantly increased,while the level of IgE showed no significant changes.It was also found the expression of IL-25 was markedly positively correlated with the levels of eosinophils and IL-4 in serum and markedly negatively correlated with the levels of IFN-γ and had no relatio.