Analysis of prognostic relationship between absolute lymphocyte count and patients with multiple myeloma
10.3969/j.issn.1000-8179.20121876
- VernacularTitle:淋巴细胞绝对计数与多发性骨髓预后的相关性分析
- Author:
Ruifang YANG
;
Zhihong ZHAO
;
Peng ZHANG
- Publication Type:Journal Article
- Keywords:
absolute lymphocyte count;
multiple myeloma;
prognosis
- From:
Chinese Journal of Clinical Oncology
2013;(20):1224-1226
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the relationship between peripheral blood absolute lymphocyte count (ALC) and patients with multiple myeloma (MM). Methods:We obtained clinical features and follow-up data of 102 patients with MM to analyze the prog-nostic value of peripheral blood ALC. Results:Patients with ALC>1.51×109/L were designated as group 1, whereas patients with ALC<1.51×109/L were designated as group 2. Group 1 had significantly lower age as well as concentrations of lactate dehydrogenase (LDH) andβ2-MG than group 2 (P<0.05). The overall survival (OS) of group 1 was significantly higher than group 2 (P<0.05). Sex, ALB, Du-rie-Salmon stage, isotype, subgroup, and stage according to the International Staging System in group 1 were not significantly different compared with group 2 (P>0.05). Conclusion:Lower ALC is a poor prognosis factor. ALC may be an important prognostic factor of MM.
