Application of Systems Biology in TCM Syndrome Classification of Chronic Hepatitis B and Posthepatitic Cirrhosis
10.11842/wst.2013.06.004
- VernacularTitle:慢性乙型肝炎及其肝炎后肝硬化中医证候分类的系统生物学研究
- Author:
Yiyu LU
;
Yanan SONG
;
Guibiao ZHANG
;
Yongyu ZHANG
;
Shibing SU
- Publication Type:Journal Article
- Keywords:
Chronic hepatitis B;
posthepatitic cirrhosis;
systems biology;
traditional Chinese medicine;
TCM syndrome classification
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2013;(6):1281-1287
- CountryChina
- Language:Chinese
-
Abstract:
The characteristics and advantages of traditional Chinese medicine ( TCM ) diagnosis and treatment of chronic liver diseases are conducted on the individualized treatment based on TCM syndrome classification . In this study , the analysis of systems biology was carried out for TCM syndrome classification in chronic hepatitis B and posthepatitic cirrhosis . The relationship between TCM syndrome classification and genetic polymorphism , the difference of genes and protein expression profiles , the difference of urine metabolite , and the molecular mechanism of Different TCM Syndrome for Same Disease and Same TCM Syndrome for Different Diseaseswere discussed . The results showed that there are molecular biological basis in TCM syndrome classification in hepatitis B and posthepatitic cirrhosis . The systems biology based syndrome identification methods may be bene-ficial to form a new classification , and provide reference for the diagnosis and individual therapy of hepatitis B and posthepatitic cirrhosis .
