Study on Pathogenesis of Tic Disorders Accompanied by Chronic Rhinitis Among 258 Cases
10.11842/wst.2013.06.020
- VernacularTitle:258例抽动障碍与慢性鼻炎共存的发病机制探讨
- Author:
Ji LI
;
Fei HAN
- Publication Type:Journal Article
- Keywords:
Tic disorders;
chronic rhinitis;
central neurotransmitter;
pathogenesis
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2013;(6):1364-1369
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to explore the tic disorders ( TD ) pathogenesis induced by chronic rhinitis . A total of 400 TD children were all investigated with self-made TD general questionnaire , Yale Global Tic Severity Scale ( YGTSS ) , TD diagnostic criteria by DSM-IV , chronic rhinitis diagnostic criteria by Zhu-Fu-Tang Textbook of Pediatrics ( 7th edition ) . A total of 258 TD children accompanied with chronic rhinitis were screened . Levels of peripheral blood T lymphocyte subsets , immunoglobulins , IL-6 , TNF-α and other related immunological indexes were detected to analyze pathogenesis. The results showed that the nose movement symptom scores of TD children with rhinitis were higher than the score of TD children without rhinitis . The score of arm-lifting and hand movement in TD children with rhinitis was lower than the score in the TD children without rhinitis . And the YGTSS score of TD children with rhinitis was higher than TD children without rhinitis. Compared with TD children without rhinitis, the level of peripheral blood T lymphocyte subsets in TD children with rhinitis was obviously reduced ( P < 0 . 05 ) . Compared with TD children without rhinitis , the level of immunoglobulins in TD children with rhinitis was slightly reduced . The level of IL-6 in TD children with rhinitis tended to increase , but the level of TNF-α tended to reduce . It was concluded that chronic rhinitis is one of the factors to induce TD .